Activation of the Maternal Immune System During Pregnancy Alters Behavioral Development of Rhesus Monkey Offspring
نویسندگان
چکیده
منابع مشابه
Activation of the maternal immune system during pregnancy alters behavioral development of rhesus monkey offspring.
BACKGROUND Maternal infection during pregnancy is associated with an increased risk of schizophrenia and autism in the offspring. Supporting this correlation, experimentally activating the maternal immune system during pregnancy in rodents produces offspring with abnormal brain and behavioral development. We have developed a nonhuman primate model to bridge the gap between clinical populations ...
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Schizophrenia and autism are thought to result from the interaction between a susceptibility genotype and environmental risk factors. The offspring of women who experience infection while pregnant have an increased risk for these disorders. Maternal immune activation (MIA) in pregnant rodents produces offspring with abnormalities in behavior, histology, and gene expression that are reminiscent ...
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ژورنال
عنوان ژورنال: Biological Psychiatry
سال: 2014
ISSN: 0006-3223
DOI: 10.1016/j.biopsych.2013.06.025